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完整的透化肌原纖維測(cè)試系統(tǒng)

溫度調(diào)節(jié)組織浴

簡(jiǎn)單安裝在倒置顯微鏡上

計(jì)算機(jī)控制的電動(dòng)XYZ微定位平臺(tái)

包括緩沖閥和解決方案切換器控制器

控制和測(cè)量力，長(zhǎng)度和肌節(jié)間距

測(cè)量力-pCa，kTr，剛度，長(zhǎng)度 - 張力和力 - 速度關(guān)系

與Aurora Scientific 900B高速視頻Sarcomere長(zhǎng)度系統(tǒng)（HVSL）無縫連接

參考文獻(xiàn)：

Schappacher-Tilp, Gudrun et al. “Computing Average Passive Forces in Sarcomeres in Length-Ramp Simulations .” PLoS Computational Biology 12.6 (2016): e1004904.

Cornachione, Anabelle S. et al. “The increase in non-cross-bridge forces after stretch of activated striated muscle is related to titin isoforms.” American Journal of Physiology - Cell Physiology 310.1 (2016): C19-C26.

Leite, Felipe S. et al. “Reduced passive force in skeletal muscles lacking protein arginylation.” American Journal of Physiology - Cell Physiology 310.2 (2016): C127-135.

Powers, Krysta et al. “Decreased force enhancement in skeletal muscle sarcomeres with a deletion in titin.” Journal of Experimental Biology 219.9 (2016): 1311-1316.

Minozzo, Fábio C., David Altman, and Dilson E. Rassier. “MgADP activation contributes to force enhancement during fast stretch of isolated skeletal myofibrils.” Biochemical and Biophysical Research Communications 463.4 (2015): 1129-1134.

Philippou, Anastassios et al. “Masticatory muscles of mouse do not undergo atrophy in space.” The FASEB Journal 29.7 (2015): 2769-2779.

Rassier, Dilson, and Aleksander Labuda. “Method and apparatus for measuring cantilever deflection in constrained spaces.” (2014): U.S. Patent No. 8,667,611.

Cornachione, Anabelle S. et al. “Arginylation of Myosin Heavy Chain Regulates Skeletal Muscle Strength.” Cell Reports 8.2 (2014): 470-476.

Yamada, Takashi et al. “Nitrosative modifications of the Ca2+ release complex and actin underlie arthritis-induced muscle weakness.” Annals of the Rheumatic Diseases 74.10 (2014): 1907-1914.

Ribeiro, Paula A.B. et al. “Contractility of myofibrils from the heart and diaphragm muscles measured with atomic force cantilevers: Effects of heart-specific deletion of arginyl-tRNA-protein transferase.” International Journal of Cardiology 168.4 (2013): 3564-3571.

Labuda, Aleksander et al. “Optical detection system for probing cantilever deflections parallel to a sample surface.” Review of Scientific Instruments 82.1 (2011): 013701.

Rassier, Dilson E. “Striated Muscles: From Molecules to Cells.” Advances in Experimental Medicine and Biology Muscle Biophysics (2010): 1-6.

Joumaa, Venus, Walter Herzog, and Dilson E. Rassier. “904-Plat Critical Sarcomere Length Extension and Phase Transition Of Force During Lengthening Of Skeletal Muscle Myofibrils.” Biophysical Journal 94.2 Supplement (2008): 305-307.

1700A肌原纖維系統(tǒng)是第***個(gè)商業(yè)化的肌原纖維系統(tǒng)，專門用于測(cè)量單個(gè)肌原纖維激活產(chǎn)生的納米牛頓力。這是***個(gè)完整的測(cè)試系統(tǒng)，包括表征肌原纖維收縮所需的所有硬件。1700A包括：470A肌原纖維原子力顯微鏡（AFM）傳感器，340A壓電長(zhǎng)度控制器，溫控浴槽，470A-XYZ電動(dòng)平移臺(tái)，820A雙XYZ運(yùn)動(dòng)控制器，用于計(jì)算機(jī)控制AFM懸臂和玻璃針定位，溶液閥控制器，解決方案切換電機(jī)驅(qū)動(dòng)器和我們的實(shí)時(shí)Linux 600A數(shù)據(jù)采集系統(tǒng)。

470 Myofibril AFM傳感器利用原子力顯微鏡和光束偏轉(zhuǎn)方法測(cè)量單個(gè)肌原纖維激活產(chǎn)生的納米牛頓力。肌原纖維固定在AFM懸臂和玻璃針之間，AFM懸臂用作高靈敏度力傳感器，玻璃針連接到340A壓電長(zhǎng)度控制器?？刂崎L(zhǎng)度和測(cè)量力使1700A肌原纖維系統(tǒng)能夠提供肌原纖維的完整機(jī)械表征。根據(jù)所使用的懸臂，滿量程力為1-10μN(yùn)，驚人的分辨率為1nN。

1700A包含溫度調(diào)節(jié)組織浴以及緩沖液交換系統(tǒng)的控制，這是快速激活任何肌原纖維的關(guān)鍵組分。該設(shè)備可以很容易地安裝在倒置顯微鏡上，為浴缸和肌原纖維提供方便和清晰的通道。

用于肌原纖維機(jī)械表征的可定制方案可以使用我們的600A數(shù)據(jù)采集系統(tǒng)進(jìn)行，當(dāng)與我們的可選900B / 901C VSL肌節(jié)長(zhǎng)度測(cè)量軟件結(jié)合使用時(shí)，研究人員可以控制和測(cè)量長(zhǎng)度，力和肌節(jié)長(zhǎng)度。