完整的透化肌細(xì)胞測(cè)試系統(tǒng)
溫控8孔浴板(尺寸從400μL到1900μL)
大電池安裝區(qū)域和電動(dòng)XYZ微定位平臺(tái),帶電腦控制
控制和測(cè)量力,長(zhǎng)度和肌節(jié)間距(可選900B / 901C)
可與Aurora Scientific 900B / 901C Sarcomere長(zhǎng)度軟件(VSL / HVSL)集成
簡(jiǎn)單安裝到倒置顯微鏡
測(cè)量力-pCA,kTR,剛度,長(zhǎng)度 - 張力和力 - 速度關(guān)系
包括用于測(cè)量細(xì)胞深度的可選光學(xué)棱鏡
參考文獻(xiàn):
K?tter, Sebastian et al. “Human myocytes are protected from titin aggregation-induced stiffening by small heat shock proteins.” The Journal of Cell Biology 204.2 (2014): 187-202.
Alegre-Cebollada, Jorge et al. “S-glutathionylation of cryptic cysteines enhances titin elasticity by blocking protein folding.” Cell 156.6 (2014): 1235-1246.
Hamdani, Nazha et al. “Deranged myofilament phosphorylation and function in experimental heart failure with preserved ejection fraction.” Cardiovascular Research 97.3 (2013): 464-471.
Chung, Eunhee and Gary M. Diffee. “Effect of aging on power output properties in rat skinned cardiac myocytes.” The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 66.12 (2011): 1267-1273.
Horiguchi, Hiroshi et al. “Fabrication and evaluation of reconstructed cardiac tissue and its application to bio-actuated microdevices.” IEEE Transactions on NanoBioscience 8.4 (2009): 349-355.